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An AI-powered patient matching engine built on InterSystems IRIS, utilizing Vector Search and Natural Language Processing (NLP) to find clinically similar patients across FHIR repositories

What's new in this version

  • New Modern UI Added: Launched a completely redesigned, intuitive dashboard built with Angular 18+ for an enhanced user experience.
  • FHIR-Compliant Application: Standardized the entire data layer to be fully compliant with FHIR R4 specifications for seamless interoperability.
  • FHIR Server Connectivity & Patient Creation: Implemented direct integration with the InterSystems FHIR server, allowing users to register and store new Patient resources.
  • FHIR Patient Directory: Added a comprehensive view to retrieve and manage existing patient records directly from the FHIR repository.
  • Instant Similarity Search: Enabled immediate vectorization; as soon as a new Condition is created on the FHIR server, it is available for semantic similarity searching.
  • UI Enhancements: Refined the overall interface with performance optimizations and a cleaner, more responsive design.
  • Login Implementation: Introduced a dedicated login screen to manage authenticated access to the clinical engine and patient data.
  • Optimized IRIS FHIR Repository Utilization: Enhanced the backend logic to effectively leverage the native power and scalability of the InterSystems IRIS FHIR repository.

iris-medmatch 🏥🤖

An AI-powered patient matching engine built on InterSystems IRIS, utilizing Vector Search and Natural Language Processing (NLP) to find clinically similar patients across FHIR repositories.

🚀 Overview

iris-medmatch bridges the gap between traditional healthcare data and modern AI. While standard searches look for exact words, this engine understands clinical intent.

Example: It can match a patient with “Hypertension” to a search for “High Blood Pressure” using mathematical vector similarity.

✨ Key Features

  • Semantic Search: Uses all-MiniLM-L6-v2 embeddings to vectorize clinical conditions.
  • Vector Database: Leverages the native VECTOR data type in InterSystems IRIS 2024.1+.
  • FHIR R4 Ready: Fully compatible with standard Patient and Condition resources.
  • Embedded Python: Runs AI models directly inside the database for zero-latency inference.
  • Modern UI: Angular-based dashboard to visualize similarity scores and patient data.

🛠️ Tech Stack

  • Core: InterSystems IRIS , Embedded Python, InterSystems FHIR Server, Vector search
  • AI: Python, ONNX Runtime, HuggingFace Transformers
  • Frontend: Angular 18+
  • DevOps: Docker & Docker Compose

📦 Getting Started

Prerequisites

  • Docker Desktop
  • InterSystems IRIS for Health 2024.1+ (Community Edition works great)

⚙️ Installation

Clone the Repository

git clone https://github.com/AshokThangavel/iris-medmatch.git
cd iris-medmatch

Running the Application with Docker

Build and start the app using Docker Compose:

docker-compose up --build

Stopping the Application

To stop and remove the running containers:

docker-compose down

In your README.md, the “Usage” section explains how a developer actually interacts with the project once the Docker containers are running.

Here is a clear breakdown you can use to explain these two endpoints:


🖥️ Usage & Access Points

Once the project is started, you can access the different layers of the application via these URLs:

1. Frontend Interface (Angular)

  • URL: http://localhost:8080
  • What it is: This is the user-facing dashboard.
  • What you can do here: * Search for patients using natural language.
  • Interact with the FHIR data visualized in a clean, modern UI.

2. Backend Management (InterSystems IRIS)

🚀 Application Walkthrough

1. Authentication

  • Demo Credentials: User: _SYSTEM | Pass: SYS
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2. Semantic Similarity Search (The “Wow” Factor)

This module uses Vector Search to understand medical synonyms and clinical intent.

  • How it works: A search for “Cardiac Issues” will mathematically find “Myocardial Infarction” by comparing their vector positions in IRIS.
  • Tech Highlight: Uses Embedded Python to vectorize the search query and Native IRIS SQL to calculate similarity scores in sub-seconds.
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3. Patient Directory & Condition Enrichment

This module manages existing FHIR resources. Users can add new diagnoses through a high-performance modal.

  • The Workflow:
  1. Create Condition for the particular patient and stored into the FHIR Server. Tech Highlight: Demonstrates real-time synchronization between standard FHIR data and AI-ready Vector data.
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  1. Add condition and save into InterSystems iris fhir server
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4. New Patient Registration

A streamlined entry point for creating new Patient resources within the InterSystems ecosystem.

  • Tech Highlight: Direct interaction with the FHIR R4 Repository via standard RESTful POST requests, ensuring data is indexed and searchable immediately.
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Made with
Version
2.0.124 Feb, 2026
Ideas portal
Category
Solutions
Works with
InterSystems IRIS for HealthHealthShareTrakCare
First published
20 Feb, 2026
Last edited
24 Feb, 2026
Last checked by moderator
21 Feb, 2026Works